Reset osmostat after diuretic treatment.

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Adipsic hypernatremia with a reset osmostat.

D the wide variation in the daily intake of sodium and water, plasma osmolality and sodium are maintained within normal range by vasopressin [arginine vasopressin (AVP) or antidiuretic hormone (ADH)] secretion and thirst. The osmotic threshold for AVP secretion is 283 mOsm/kg and for thirst sense is 293 mOsm/kg. Hence, by the time plasma osmolality reaches the osmotic threshold for thirst, AVP ...

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Normal fractional urate excretion identifies hyponatremic patients with reset osmostat.

BACKGROUND Reset osmostat (RO) occurs in 36% of patients with syndrome of inappropriate antidiuretic hormone secretion (SIADH) and is not often considered when evaluating hyponatremic patients. Patients with RO are not usually treated, but recent awareness that symptoms are associated with mild hyponatremia creates a therapeutic dilemma. We encountered patients with hyponatremia, hypouricemia a...

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A case of persistent hyponatraemia due to reset osmostat.

We report a case of a 65 year old Malay lady with long-standing diabetes mellitus, who presented to our institution with a one month history of worsening neck pain and progressive upper and lower limb weakness. She was stable despite severe hyponatraemia which was initially treated as syndrome of inappropriate anti-diuretic hormone (SIADH). This was consistent with her underlying illness which ...

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Reset Osmostat in an Infant with Failure to Thrive

We are reporting an infant who was presented to our institution exhibiting a failure to thrive and hyponatremia. An extensive renal evaluation revealed resistive hyponatremia with normal renal glomerular and tubular function. Patient remained hyponatremic even after fluid restriction, salt loading and Fludrocortisone (Florinef) administration. Water deprivation and water loading tests were sugg...

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Reset osmostat in a 47-year-old woman with cerebral palsy.

The reset osmostat variation of the syndrome of inappropriate antidiuretic hormone (SIADH) is thought to account for up to one third of SIADH cases. Most commonly, it can cause hyponatremia in patients who are quadriplegic, psychotic, or chronically malnourished, such as those with tuberculosis or alcoholism. Recent case reports have also noted the reset osmostat in several other states, includ...

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ژورنال

عنوان ژورنال: BMJ

سال: 1977

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.2.6094.1063